Lab Senior Scientist (Equivalent to Research Associate Professor), Department of Psychiatry Twitter | LinkedIn ORCID ID: 0000-0002-7866-6983 reeteka@gmail.com Resilience and representation in research: In conversation with Reeteka Sud Stress primes brain hub to trigger freezing for unrelated fears Back Back to People Page Back Co-Investigator Team Stem Cell Research Dr Reeteka Sud Lab Senior Scientist (Equivalent to Research Associate Professor), Department of Psychiatry How can patient-derived stem cells help connect the dots, from genomic risk to clinical diagnosis -- this is the unifying research theme for my various projects. My expertise lies broadly at the intersection of Genetics, Neuroscience and Psychiatry. I head the CBM Biorepository at NIMHANS, where we bank biospecimen from psychiatric patients, including stem cells, DNA, plasma and serum. I am also very passionate about scicomm/public outreach on mental health conditions Select Publications 2026 PrecInNor: An Indo-Norway collaborative programme for precision psychiatry training | Asian J Psychiatry 2025 Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group | Molecular Psychiatry The Psychiatric Genomics Consortium: discoveries and directions | Lancet Psychiatry The measurement of agitation in neurocognitive disorders: A systematic review | Alzheimer's & Dementia 2024 Exploring Mental Health Stima in the context of Psychiatric Genetics: Insights from the ISPG Stigma Reduction SIG Survey The STEM Arena in India: A Story of Exclusion in Many Colors Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder | Oxford Open Neurosci Projects Deciphering the molecular mechanisms of treatment-resistant schizophrenia and clozapine response: To understand the genomic and cellular predictors of treatment-resistant schizophrenia (TRS) and clozapine response using genome-wide association study (GWAS) and induced pluripotent stem cells (IPSC): Here our aim is to: 1. Identify genomic factors underlying TRS and clozapine response 2. Elucidate cellular mechanisms of TRS and clozapine response in IPSC-derived organoids 3. Evaluate the translational utility of these genetic/cellular markers as predictors of TRS and clozapine response using existing prospective cohorts (Funding from PGRN, BFI Foundation) Subcellular Dynamics in Neuropsychiatric Disorders: Our recent work highlights the manifold ways in which sub-cellular organelles may be driving disease pathogenesis. We discovered connections between APOE genotype and ribosome biogenesis, which could be significant for ADRD pathogenesis, and is currently under investigation. We are also using techniques like ExM to study how cytoskeletal structures mediate the workings of antipsychotic drugs, and by extension, be affected in psychotic disorders. (Funding from Ben Barres Award, Axilor Labs) Key Research Outputs (C) Direction of migration. C1-C3 cells migrated in a relatively directional pattern. B1 and B2 cells, however, migrated in a random, non-directed manner. Both BD lines showed back-and-forth movement, and directional and circular patterns of migration. (D) Sample migratory paths of control and patient-derived lines over 15 h. Abnormalities in the migration of neural precursor cells in familial bipolar disorder The trajectories of migrating neural precursors lay the foundations of the developing central nervous system. Here we demonstrate identifiable cellular abnormalities in NPCs derived from BD patients. The BD patients in this study were chosen from a dense family, who had multiple rare damaging variants implicated in cellular migration, and had structural abnormalities noted on brain MRI scans ( Fig. 1 A). Cellular migration analysis showed that although patient-derived NPCs showed a random trajectory, the NPCs from healthy controls migrated towards other cells (directed/ballistic movement) ( Fig. 1 C-D). Integration of deep clinical phenotyping with investigations into cellular mechanisms in patient-derived IPSCs, as reported here, can provide much-needed comprehensive understanding of psychiatric disorders. Cell cycle abnormality is a cellular phenotype in OCD A critical and yet unanswered question in Psychiatry is how might clinical phenotypes manifest in terms of cellular readouts. This study was conducted to determine differences in cell cycle in patient-derived cells vs controls A) Illustrates the placement of Indian samples between European and East Asian clusters, highlighting notable regional variability. Asian PCA with HGDP samples. B) Presents a north-south ancestral gradient, correlated with latitude. SVM predictions. C) Decile-based risk stratification in BD A cross ancestry genetic study of psychiatric disorders from India We estimated the extent of population stratification as well as the predictive accuracy of polygenic scores (PGS) derived from European samples to a data set from India. Our analyses reveal global and continental PCA overlap with other South Asian populations. Admixture analysis revealed a north-south genetic axis within India (FST 1.6%). The Bayesian PGS analyses indicates moderate-to-high predictive power for BD.

Project Scientist B (Non- Medical) Back Back to People Page Back Lab Team Ashim Paul Deb Project Scientist B (Non- Medical)

Assistant Professor, Department of Geriatric Psychiatry LinkedIn | ResearchGate drvijaysh@yahoo.com Back Back to People Page Back Co-Investigator Team Dr Vijaykumar S Harbishettar Assistant Professor, Department of Geriatric Psychiatry

Professor, Department of Psychiatry Google Scholar Back Back to People Page Back Co-Investigator Team Dr Muralidharan Kesavan Professor, Department of Psychiatry

Lab Scientist (Equivalent to Research Assistant Professor), Department of Psychiatry Google Scholar ORCID ID: 0000-0002-6269-9449 paul.pradipp@gmail.com Back Back to People Page Back Co-Investigator Team, Lab Team Stem Cell Research, Molecular Genetics Dr Pradip Paul Lab Scientist (Equivalent to Research Assistant Professor), Department of Psychiatry Dr. Pradip Paul received his Ph.D. from NIMHANS in 2019. Ganesh, A., Paul, P. , Nadella, R., Jain, S., Purushottam, M., Viswanath, B., & Paul, P. (2024). F97. DIFFERENTIAL EXPRESSION OF MICRORNAS UPON IN VITRO LITHIUM AND VALPROATE EXPOSURE TO BIPOLAR DISORDER PATIENTS-DERIVED LCLS. European Neuropsychopharmacology , 87 , 257. https://doi.org/10.1016/j.euroneuro.2024.08.508 Gayathri, R., Manasadeepika, Shankarappa, B., Mahadevan, J., Jain, S., Sud, R., Viswanath, B., Purushottam, M., & Paul, P . (2024). F92. ASSESSMENT OF CELLULAR HEALTH ON ETHANOL-INDUCED TOXICITY IN HUMAN NEURAL PRECURSOR CELLS. European Neuropsychopharmacology , 87 , 254. https://doi.org/10.1016/j.euroneuro.2024.08.503 Mahadevan, J., Holla, B., Ganesh, S., Shankarappa, B., Paul, P. , Sud, R., Jain, S., Purushottam, M., & Viswanath, B. (2024). W32. A GENOME-WIDE ASSOCIATION STUDY OF BIPOLAR DISORDER FROM INDIA. European Neuropsychopharmacology , 87 , 118. https://doi.org/10.1016/j.euroneuro.2024.08.241 Manasadeepika, Lakshana, P., Paul, P. , Sud, R., & Viswanath, B. (2024). T99. INVESTIGATING THE LINK BETWEEN THERAPEUTIC EFFICACY OF LITHIUM AND MITOCHONDRIAL PARAMETERS. European Neuropsychopharmacology , 87 , 205–206. https://doi.org/10.1016/j.euroneuro.2024.08.409 Viswanath, B., Sud, R., Ganesh, S., Mahadevan, J., Holla, B., Paul, P. , Purushottam, M., & Jain, S. (2024). DECIPHERING THE UNDERLYING BIOLOGY OF PSYCHIATRIC DISORDERS THROUGH LONGITUDINAL FAMILY COHORT BASED STUDIES IN INDIA. European Neuropsychopharmacology , 87 , 43–44. https://doi.org/10.1016/j.euroneuro.2024.08.108

Clinical Post Doctoral Fellow (Equivalent to Senior Resident, Psychiatry) arushisingh2707@gmail.com Back Back to People Page Back Clinical Team Dr Arushi Singh Clinical Post Doctoral Fellow (Equivalent to Senior Resident, Psychiatry)

Professor, Department of Psychiatry LinkedIn | Google Scholar sivakumar.nimhans@gmail.com Back Back to People Page Back Co-Investigator Team Dementia Dr P T Sivakumar Professor, Department of Psychiatry

Data Supervisor varalakshmir93@gmail.com Back Back to People Page Back Admin Team Varalakshmi R Data Supervisor

Back Back to People Page Back Clinical Team Dineshbabu P

Laboratory Technician Back Back to People Page Back Lab Team Deepthi R Laboratory Technician Deepthi R is a Laboratory technician at the Centre for Brain and Mind, holding a Master's degree in Medical Laboratory Technology.With a strong foundation in clinical and research laboratory practices, she supports high-quality diagnostics

Scientific Development & Communication Officer Instagram | Twitter | LinkedIn ORCID ID: 0000-0001-5616-8003 cbm.nimhans@gmail.com Writing Making research inclusive: Bringing patients and the public into the fold The Great Divide: India and Mental Illness | MIND: The Gap Variations in Bipolar Disorder: Insights from and Treatment Implications in Indian Patients De-stigmatizing mental health care in India: a way forward Back Back to People Page Back Communication Team Anushka Banerjee Scientific Development & Communication Officer Anushka leads science communication efforts at the Centre for Brain and Mind. With a Masters degree in Molecular Medicine, Anushka has experience in research, science communication and public outreach. She enjoys photography, watching Hindi films and exploring restaurants in her spare time. Projects mglnimhans.org An informal, safe and supportive outreach approach to bridge the Mental Health Gap in India | IndiaBioscience Outreach Grant With support from the IndiaBioscience Outreach Grant, we created platforms for scientists, clinicians, patients, caregivers, and general public to connect and share insights. Through awareness events, expert interviews, an art competition, and an e-book, we sparked conversations on mental health, tackled stigma, and made research more accessible. www.mglnimhans.org Coffee, Cinema and Community: Redefining Mental Health | MGL NIMHANS

Assistant Professor, Department of Psychiatry Google Scholar srinivasbalachander@gmail.com Back Back to People Page Back Co-Investigator Team Dr Srinivas Balachander Assistant Professor, Department of Psychiatry