Co-Investigator Team
Stem Cell Research
Dr Reeteka Sud
Lab Senior Scientist (Equivalent to Research Associate Professor), Department of Psychiatry
How can patient-derived stem cells help connect the dots, from genomic risk to clinical diagnosis -- this is the unifying research theme for my various projects. My expertise lies broadly at the intersection of Genetics, Neuroscience and Psychiatry. I head the CBM Biorepository at NIMHANS, where we bank biospecimen from psychiatric patients, including stem cells, DNA, plasma and serum. I am also very passionate about scicomm/public outreach on mental health conditions
Select Publications
2026
2025
2024
Projects
Deciphering the molecular mechanisms of treatment-resistant schizophrenia and clozapine response:
To understand the genomic and cellular predictors of treatment-resistant schizophrenia (TRS) and clozapine response using genome-wide association study (GWAS) and induced pluripotent stem cells (IPSC): Here our aim is to:
1. Identify genomic factors underlying TRS and clozapine response
2. Elucidate cellular mechanisms of TRS and clozapine response in IPSC-derived
organoids
3. Evaluate the translational utility of these genetic/cellular markers as predictors of TRS and clozapine response using existing prospective cohorts
(Funding from PGRN, BFI Foundation)
Subcellular Dynamics in Neuropsychiatric Disorders: Our recent work highlights the manifold ways in which sub-cellular organelles may be driving disease pathogenesis. We discovered connections between APOE genotype and ribosome biogenesis, which could be significant for ADRD pathogenesis, and is currently under investigation. We are also using techniques like ExM to study how cytoskeletal structures mediate the workings of antipsychotic drugs, and by extension, be affected in psychotic disorders.
(Funding from Ben Barres Award, Axilor Labs)