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Genetics and Stem Cell Group

Molecular disturbances involving multiple genes contribute to the complexity of psychiatric disorders, requiring a focus on cellular and molecular changes. Advances in stem cell technology allow us to investigate specific molecular mechanisms underlying neuropsychiatric disorders and offer insights into genetic variations and their effects on neuronal functioning in neural cell models using induced pluripotent stem cells (iPSCs). This offers potential for improved diagnostic and therapeutic approaches.

Affiliated Labs and Centre
 

Facilities

Featured Publications

Janardhanan M, Sen S, Shankarappa B, Purushottam M. Molecular genetics of neuropsychiatric illness: some musings. Front Genet. 2023;14:1203017. Published 2023 Nov 1. doi:10.3389/fgene.2023.1203017

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Shankarappa B, Mahadevan J, Murthy P, et al. Hypomethylation of Long Interspersed Nucleotide Elements and Aldehyde Dehydrogenase in Patients of Alcohol Use Disorder with Cirrhosis. DNA Cell Biol. 2023;42(7):364-371. doi:10.1089/dna.2022.0669

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Sukumaran SK, Paul P, Guttal V, et al. Abnormalities in the migration of neural precursor cells in familial bipolar disorder. Dis Model Mech. 2022;15(10):dmm049526. doi:10.1242/dmm.049526

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Ratna N, Pasupulati SL, Nadella RK, Purushottam M, Jain S. Complexities in Genetic Counseling and Testing of Huntington's Disease: A Perspective from India. Neurol India. 2022;70(5):2141-2144. doi:10.4103/0028-3886.359184

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Paul P, Iyer S, Nadella RK, et al. Lithium response in bipolar disorder correlates with improved cell viability of patient derived cell lines. Sci Rep. 2020;10(1):7428. Published 2020 May 4. doi:10.1038/s41598-020-64202-1

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Timothy A, Benegal V, Shankarappa B, Saxena S, Jain S, Purushottam M. Influence of early adversity on cortisol reactivity, SLC6A4 methylation and externalizing behavior in children of alcoholics. Prog Neuropsychopharmacol Biol Psychiatry. 2019;94:109649. doi:10.1016/j.pnpbp.2019.109649

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Viswanath B, Rao NP, Narayanaswamy JC, et al. Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science. BMC Psychiatry. 2018;18(1):106. Published 2018 Apr 18. doi:10.1186/s12888-018-1674-2​

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