Clinical Group Genetics and Stem Cell Group Endophenotype Group Endophenotypes are measurable and heritable traits or behaviors linked to a disorder, that sit between the genetic factors and the observable symptoms of the condition. Psychiatric disorders are increasingly viewed as neurodevelopmental disorders, which are influenced by genetic, epigenetic & environmental factors. These clues offer insights into genetic underpinnings of these disorders. Utilising endophenotypes derived from various assessments like neuroimaging can enhance the reliability of research on brain function. Dr. John P. John Professor, Department of Psychiatry Dr. Venkatasubramanian Ganesan Professor, Department of Psychiatry Dr. Jitender Saini Professor, Department of Neuro Imaging & Interventional Radiology Dr Bharath Holla Associate Professor, Department of Psychiatry Dr. Sreeraj V S Associate Professor, Department of Psychiatry Affiliated Labs and Centre ADBS Neuroimaging Centre (ANC) Centre for Brain Mapping (CBM) Translational Psychiatry Lab (TransPsych) Multi-modal Brain Imaging Analysis Lab (MBIAL) Facilities Eye Tracking Functional Near-Infrared Spectroscopy (fNIRS) MRI Scanner Philips Ingenia 3.0T CX MRI EEG Featured Publications Parekh P, Vivek Bhalerao G; ADBS consortium, John JP, Venkatasubramanian G. Sample size requirement for achieving multisite harmonization using structural brain MRI features. Neuroimage. 2022;264:119768. doi:10.1016/j.neuroimage.2022.119768 Lakkireddy SP, Balachander S, Dayalamurthy P, et al. Neurocognition and its association with adverse childhood experiences and familial risk of mental illness. Prog Neuropsychopharmacol Biol Psychiatry. 2022;119:110620. doi:10.1016/j.pnpbp.2022.110620 Bhalerao GV, Parekh P, Saini J, Venkatasubramanian G, John JP; ADBS consortium. Systematic evaluation of the impact of defacing on quality and volumetric assessments on T1-weighted MR-images. J Neuroradiol. 2022;49(3):250-257. doi:10.1016/j.neurad.2021.03.001 Parekh P, Bhalerao GV, Rao R, et al. Protocol for magnetic resonance imaging acquisition, quality assurance, and quality check for the Accelerator program for Discovery in Brain disorders using Stem cells. Int J Methods Psychiatr Res. 2021;30(3):e1871. doi:10.1002/mpr.1871 Holla B, Dayal P, Das A, et al. Transdiagnostic neurocognitive endophenotypes in major psychiatric illness. medRxiv (Cold Spring Harbor Laboratory). February 2020. doi:10.1101/2020.02.14.20022863

Participate in Our Research Be a part of our groundbreaking research initiatives by volunteering! You can explore the dedicated pages for each research group to learn more about the innovative studies our scientists are conducting. Our research delves into understanding the complexities behind severe psychiatric illnesses. Our studies may involve - non-invasive methods like EEG recordings, where sensors are placed on the scalp to capture brainwave activity MRI brain scans simple measurements of button-press responses or eye movements blood sample which will be used for genetic and stem cell studies For more information, please read the “Information & Consent Forms” (links to the PDF documents in various languages are given below) If you are eager to participate as a research volunteer, you can register by filling out the form below . Once registered, we will reach out to you when a suitable study becomes available. Your involvement plays a crucial role in advancing our understanding of the human brain, and we welcome you to be a part of our exciting journey in pushing the boundaries of scientific exploration. Information and Consent Forms (PDF) Control (Unaffected Persons) Patient Relatives English Kannada Hindi Tamil Telugu Malayalam English Kannada Hindi Tamil Telugu Malayalam English Kannada Hindi Tamil Telugu Malayalam

Research Overview The Rohini Nilekani Centre for Brain and Mind tackles the global challenge of psychiatric disorders with a pioneering study focusing on high-risk families. Clinical investigations, including neuroimaging and neuropsychological assessments, are conducted on these cohorts regularly. Through our collaborations with NCBS, patient blood samples are used to establish disease-specific cellular models using immortalised cell lines and induced pluripotent stem cells (iPSCs). Clinical Group Endophenotype Group Genetics and Stem Cell Group By analysing these patient-derived cell lines through genetic studies & cell-based assays, alongside large-scale clinical data, our research aims to unravel the complex relationship between cellular phenotypes and psychiatric disorder progression. This interdisciplinary approach promises to advance our understanding and facilitate the development of innovative therapies, ultimately improving mental health outcomes. For Researchers For General Public Clinical Assessments Our clinicians conduct comprehensive evaluations of patients’ behaviours and symptoms. This is followed by a psychiatric screening that assesses family history, charts hereditary traits & measures the severity of the disorder. Neuropsychological tests evaluate cognitive skills in individuals with & without psychiatric disorders, considering their family history Genetic Studies We assess changes in DNA sequence in psychiatric patients, their immediate relatives & in unrelated controls (people without a psychiatric diagnosis). Understanding why & how these changes happen can help scientists understand how genetic risk translates to disease. Multimodal Neuroimaging We use imaging techniques such as eye-movement tracking, functional near-infrared spectroscopy, MRIs and EEGs. These help us evaluate the structural changes in the brain & its activity linked to psychiatric diseases. Bioinformatics Using powerful computers, we study differences in the DNA of individuals with & without psychiatric disorders in different populations. This genetic information helps us find the cause & predict the chances of developing these psychiatric disorders. Stem Cell Research Stem cells, developed from blood cells, are used to investigate differences in brain cells during disease. We study whether these cells function differently than those of non-affected people. Clinical Assessment Our doctors examine you for the presence of any psychiatric disorders & take a blood sample. They make a chart of your family history to understand if any psychiatric disorder runs in your family. They also assess how severe your disorder is & evaluate your cognitive skills. Brain Imaging Our researchers use different methods to peek inside the brain and check for any changes in its structure & function. EEG records the electrical signals from the brain. It helps us find changes in brain activity. We also use other techniques such as eye tracking & near infrared spectroscopy to study different forms of brain activity and function. MRI uses a powerful magnet to take detailed pictures of your brain, and allows doctors to check the structure for any potential abnormalities. Genetic Studies Remember the blood sample we took? We isolate DNA from blood cells & study the genetic sequence. We try to understand whether changes in the DNA are linked to certain psychiatric disorders. We also aim to understand the differences in DNA sequences using mathematical models. This helps us learn if these differences make it more likely for someone to develop psychiatric symptoms. Stem Cell Research We also use blood samples to create stem cells, which are special cells that can grow into many different kinds of cells in the body. We turn them into brain cells to understand how they function in people with & without psychiatric disorders. All of this information together, helps us understand psychiatric disorders better & can lead to development of better treatments!

Publications (Please right-click on links to "open in a new tab")

In the News 2025-11-10 Awareness, not algorithms, must guide mental health: Neurologists at Manotsava in Bengaluru Know more 2025-04-05 Stabilizing DNA Repeats: New Study Shows Promising Path To Treat SCA12 The study findings suggest that protecting DNA from mutations in brain cells could offer a viable treatment strategy for SCA12. Know more 2025-04-02 Making research inclusive: Bringing patients and the public into the fold Public and Patient Involvement and Engagement is transforming research around the globe - will India chime in? Know more 2024-10-30 ADHD to anxiety—Bengaluru’s mental health festival destigmatises disorders, diseases The festival, Mannotsava, was co-hosted by Rohini Nilekani Philanthropies, the National Institute of Mental Health and Neurosciences, and the National Centre for Biological Sciences. Know more 2024-10-10 Understanding Mental Health Across the Lifespan: A Conversation with Dr Biju Viswanath Do long working hours lead to mental illness, and if so, will it be untreatable? These are questions many of us grapple with while navigating workplace challenges. In this interview, Dr Biju Viswanath, a Clinical and Public Health Intermediate Fellow, addresses some related concerns. Know more 2024-07-24 Understanding how and why people go mad has been a critical aspect of human society Dr. Sanjeev Jain, author of Mindscape and Landscape: An Illustrated History of NIMHANS, offered insights into the history of mental health at an event in Bengaluru Know more 2024-07-21 Experts urge sensitive depiction of mental health in films Experts discuss cinema’s impact on mental health at an event in NINMHANS in Bengaluru on Saturday. Know more 2024-03-26 Matters of mind and art The Centre for Brain and Mind at NIMHANS, a research venture launched in 2023, will commemorate World Bipolar Day on March 30 the birthday of the iconic artist Vincent van Gogh, by delving into the captivating fusion of science and art. Know more 2024-03-10 Variations in Bipolar Disorder: Insights from and Treatment Implications in Indian Patients The DBT/Wellcome Trust India welcomed 15 Early Career Fellows this year. This article introduces the research project of Dr. Biju Viswanath, DBT/WT India Alliance Intermediate Fellow in the Clinical and Public Health. Know more Read More

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सोम, 15 जुल॰ | Bengaluru Coffee, Cinema and Community: Mental Health Redefined समय और स्थान 15 जुल॰ 2024, 9:00 am – 21 जुल॰ 2024, 7:00 pm Bengaluru इवेंट के बारे में This Brain Awareness Week program will bring discussions around mental health to our beautiful city. From cafe book talks to film discussions, from art exhibitions to storytelling workshops - let's talk about mental health, Bengaluru! Scroll down and click "see all" to view the full event schedule, or view full-size poster here अधिक पढ़ें > शेड्यूल 4:00 pm - 11:59 pm 17 दिन 7 घंटे 59 मिनट Registrations Open | Through the Looking Glass: Artistic Perspectives on Mental Health 4:00 pm - 6:00 pm 2 घंटे Book Talk: Mindscape and Landscape: An Illustrated History of NIMHANS by Dr Sanjeev Jain Atta Galatta, Indiranagar 3 और आइटम उपलब्ध हैं सभी देखें यह इवेंट साझा करें

सभी (26) General Pages (19) इवेंट्स (7) "" के लिए परिणाम मिले General Pages (19) Fullscreen Page | CBM NIMHANS Participate in our research | CBM NIMHANS Participate in Our Research Be a part of our groundbreaking research initiatives by volunteering! You can explore the dedicated pages for each research group to learn more about the innovative studies our scientists are conducting. Our research delves into understanding the complexities behind severe psychiatric illnesses. Our studies may involve - ​ non-invasive methods like EEG recordings, where sensors are placed on the scalp to capture brainwave activity MRI brain scans simple measurements of button-press responses or eye movements blood sample which will be used for genetic and stem cell studies ​ For more information, please read the “Information & Consent Forms” (links to the PDF documents in various languages are given below) ​ If you are eager to participate as a research volunteer, you can register by filling out the form below . Once registered, we will reach out to you when a suitable study becomes available. Your involvement plays a crucial role in advancing our understanding of the human brain, and we welcome you to be a part of our exciting journey in pushing the boundaries of scientific exploration. Information and Consent Forms (PDF) Control (Unaffected Persons) Patient Relatives English Kannada Hindi Tamil Telugu Malayalam English Kannada Hindi Tamil Telugu Malayalam English Kannada Hindi Tamil Telugu Malayalam News | CBM NIMHANS In the News 2024-07-24 ‘Understanding how and why people go mad has been a critical aspect of human society’ Dr. Sanjeev Jain, author of Mindscape and Landscape: An Illustrated History of NIMHANS, offered insights into the history of mental health at an event in Bengaluru Know more 2024-07-21 Experts urge sensitive depiction of mental health in films Experts discuss cinema’s impact on mental health at an event in NINMHANS in Bengaluru on Saturday. Know more 2024-03-26 Matters of mind and art The Centre for Brain and Mind at NIMHANS, a research venture launched in 2023, will commemorate World Bipolar Day on March 30 the birthday of the iconic artist Vincent van Gogh, by delving into the captivating fusion of science and art. Know more 2024-03-10 Variations in Bipolar Disorder: Insights from and Treatment Implications in Indian Patients The DBT/Wellcome Trust India welcomed 15 Early Career Fellows this year. This article introduces the research project of Dr. Biju Viswanath, DBT/WT India Alliance Intermediate Fellow in the Clinical and Public Health. Know more 2024-01-21 Pune, now a home to India Science Fest At more than 30 interactive stalls, students can learn about science concepts, including some set up by the industry. The fest also has fun competitions in science photography, science fiction writing, explaining one’s thesis to younger children, with prizes worth Rs 5 lakh. Know more 2023-12-24 NIMHANS-led PARAM research to predict and prevent brain disorders The research will also help the medical fraternity determine the risk factors that contribute to the disorders and the impact of environmental and societal conditions on the development of the human brain. Know more 2023-11-26 Virtual screening of international dementia documentary at NIMHANS fosters... Experts emphasised the critical role of awareness and destigmatisation in addressing the challenges posed by dementia and its contribution to a holistic understanding of dementia and its impact on individuals and communities. Know more 2023-10-10 Mansukh Madaviya inaugurates Centre for Brain and Mind at NIMHANS The Centre for Brain and Mind was launched in collaboration with National Centre for Biological Sciences (NCBS) with the contribution of Rs 100 crore from Rohini Nilekani Philanthropies. Know more 2023-07-04 Rohini Nilekani Centre for Brain and Mind launched at NCBS Bengaluru The centre is an outcome of a ₹100 crore grant to NCBS and NIMHANS for long-term research, and to build capacity for both research and practice in the mental health field Know more Read More सभी देखें इवेंट्स (7) Stories in Motion: Mental Wellness through Art and Narratives by Dr. Ankit Dwivedi 21 July 2024 | 11:30 am 7, 4th Main Rd, Stage 2, Domlur, Bengaluru, Karnataka 560071, India Mental Health & Movies - The Good, The Bad & The Ugly 20 July 2024 | 1:00 pm 7, 4th Main Rd, Stage 2, Domlur, Bengaluru, Karnataka 560071, India "Mindscape and Landscape: An Illustrated History of NIMHANS" by Dr. Sanjeev Jain 17 July 2024 | 10:30 am 178, 5th Main Rd, Indira Nagar 1st Stage, 1st Stage, Indiranagar, Bengaluru, Karnataka 560038, India सभी देखें

फिलहाल प्रदर्शित करने के लिए कोई शेड्यूल नहीं है

Work With Us Career Development Fellowship The Centre for Brain and Mind (CBM) is an exciting new scientific venture of the National Institute for Mental Health & Neurosciences (NIMHANS) & National Centre for Biological Sciences (NCBS) and supported by the Rohini Nilekani Philanthropies . ​ The centre will undertake cutting-edge research in the area of human mental illness with the goal of discovering novel and better methods for the diagnosis and clinical management of mental illness in humans. Towards this goal, CBM-NIMHANS invites applications for Career Development (CD) Fellowships . The Fellowships are available across the full spectrum of research being carried out at CBM-NIMHANS, focusing on clinical neurobiology and translational research in Psychiatry . You are eligible if you are: ​ a basic (PhD) or clinical (MD/DNB) researcher within four years post-PhD/MD degree less than or equal to 50 years of age ​ The Fellowships will be hosted primarily at NIMHANS; the applicant must be willing to relocate to Bengaluru to initiate the Fellowship. The total duration will be 4 years . ​ A hypothesis-based research proposal is essential for the complete application, along with 2 letters of recommendation. The proposed research needs to align with the research goals of CBM. The applicant needs to show competence and experience to conduct the proposed research. One mentor needs to be identified from CBM, who will have to provide a letter of support. Nature of Support – Fellowship Amount - INR 1,50,000/- per month Allowances - 1 technical staff, consumables, equipment, travel costs and access to all institutional research facilities. The Fellowship has generous and flexible funds for research, and competitive personal support (equivalent to assistant professor) and require 100%-time commitment towards the fellowship project from the applicant. The application process requires the submission of a preliminary application. Applications are now open, the deadline to apply is September 17th, 2024. ​ For queries, please contact cbm.vacancies@gmail.com Apply Now