Work With Us Internships There are no internship positions currently available. Careers Project Associate (Lab) Contractual NIMHANS is conducting a walk-in selection for the post of Project Associate (Lab) on a contract basis for the project entitled “Asian Bipolar Genetics Network (A-BIG-NET)” funded by NIH USA, under Dr Biju Viswanath , Professor of Psychiatry & Principal Investigator, NIMHANS, Bengaluru - 560 029. Essential Qualification: Post Graduate Degree in Stem Cell and Regenerative Biology or relevant fields Essential Experience: At least two years of research experience in stem cell culture, molecular biology, and fluorescence microscopy techniques. Salary: Rs. 44,100/- per month (consolidated) Maximum Age Limit: 30 Years Duration: 1-year contractual; extension is contingent on the performance of the candidate. Date & Time: 24th March, 2026, 10.30 AM Venue: Board Room and Exam Hall, 4th floor, NBRC Building, NIMHANS, Bangalore 560029. Learn More Project Associate Contractual NIMHANS is conducting a walk-in selection for the post of Project Associate on a contract basis for the project entitled “Cross-disorder approach to delineate the roles of neuroinflammation in early-onset psychiatric conditions” funded by the MQ: Transforming Mental Health, under Dr Ashitha S N M , Assistant Professor & MQ Fellow, Department of Psychiatry & Principal Investigator, NIMHANS, Bengaluru - 560029. Essential Qualification: Post Graduate Degree in Life Sciences / Post Graduate Degree in Professional course (M-Tech) in Biological Sciences / Biotechnology Essential Experience: At least one year of research experience Desirable Experience: Knowledge in Western Blot, qPCR, immunocytochemistry staining techniques, iPSCs or mammalian stem cell culture, and neuroscience & imaging techniques. Preference will be given to the candidate with prior experience/interest in neurodevelopmental research. Maximum Age Limit: 35 years Salary: Rs. 42,000/- per month (consolidated) Duration: 6 months, contractual, extension is contingent on the performance of the candidate (up to the end of the project period, i.e., 29th December 2027). Date & Time: 24th March, 2026, 10.30 AM Venue: Board Room and Exam Hall, 4th floor, NBRC Building, NIMHANS, Bangalore 560029. Learn More Project Associate - II (2 Positions) Contractual NIMHANS is conducting WALK-IN-SELECTION for filling up the post of “Project Associate - II” on a contract basis for the project titled “Asian Bipolar Genetics Network (A-BIG-NET)” funded by the National Institute of Mental Health (NIMH) under Dr Biju Viswanath, Professor of Psychiatry & Principal Investigator, NIMHANS, Bengaluru - 560 029. Essential Qualification: M. Phil in Psychiatric Social Work/Master in Social Work with 3 years of clinical or research experience Maximum Age Limit: 45 years Salary: Rs.57,000/- (Consolidated) Duration: 1 year, contractual, extension is contingent on the performance of the candidate (up to the end of the project period, i.e., 31 December 2028) Date & Time: 27/03/2026 at 10:00 A Venue: Lecture Hall-1, 1st Floor, adjacent to the Department of Neurophysiology, Old Administrative Building, NIMHANS, Bangalore - 560029 Learn More Senior Resident – Radio-diagnosis (Project) Contractual NIMHANS is conducting a Walk-in Selection for filling up the post of Senior Resident – Radio-diagnosis (Project) on a contract basis for the Project entitled “Centre for Brain and Mind” funded by RNP under Dr. Y.C. Janardhan Reddy, Senior Professor, Department of Psychiatry & Principal Investigator, NIMHANS, Bengaluru 560029. Essential Qualification: MD/DNB (Radio diagnosis) OR DMRD with one-year experience Maximum Age Limit: 45 years Salary: Rs. 1,40,000/- per month (Consolidated) Duration: Initial appointment will be for 6 months and renewable every 6 months based on performance till the end of the project Date & Time: 30.03.2026 @ 10:30 AM Venue: Board Room and Exam Hall on the 4th Floor of NBRC Building, NIMHANS, Bengaluru - 560029 Learn More

The Centre for Brain and Mind (CBM-NIMHANS) focuses on supporting research on five mental disorders — schizophrenia, bipolar disorder, addiction, obsessive-compulsive disorder & dementia. The centre employs several tools & techniques to understand the complexities of brain & mind conditions. This is a collaborative effort of the National Institute for Mental Health and Neurosciences (NIMHANS) & the National Centre for Biological Sciences (NCBS), supported by Rohini Nilekani Philanthropies. Welcome Updates Research Events Jobs Rohini Nilekani Centre for Brain and Mind About Us The Centre for Brain and Mind is a collaborative, premier research centre focused on supporting research on five mental disorders — schizophrenia, bipolar disorder, addiction, obsessive-compulsive disorder and dementia. With a partnership between the National Institute of Mental Health and Neurosciences (NIMHANS) and the National Centre for Biological Sciences (NCBS), the centre employs several tools & techniques to understand the complexities of brain and mind conditions. Learn More Introduction New at CBM-NIMHANS Dr Reeteka Sud awarded the PGRN–Myriad Research Grant 2025! Clozapine is a therapeutically superior antipsychotic for treatment-resistant schizophrenia (TRS). This project is designed to investigate the utility of patients’ genomic variants, in combination with their clinical and cellular data, to identify the basis of clozapine response in TRS. Career Development Fellowship Awardee - Dr Kalyani B Karunakaran Congratulations to Dr Kalyani B Karunakaran for being awarded the Career Development Fellowship at CBM-NIMHANS! Dr Karunakaran's work focuses on the molecular mechanisms underlying cross-disorder relationships & psychiatric drugs with cross-disorder effects. Join us at Manotsava 2025! Manotsava, India's largest mental health festival, returns to Bengaluru on November 8-9, 2025 at the Lalit Ashok! Get involved in research! We're bringing together scientists, clinicians, members of the public, individuals with lived experiences and their caregivers to talk about our research in psychiatric and neurological illnesses. A Cerebellar Paradox Offers Clues in SCA12 Research Our new paper unveils a fascinating paradox: the brain region most vulnerable in SCA12 appears surprisingly resilient. New publication! CAG Repeat Instability and Region-Specific Gene Expression Changes in the SCA12 Brain Welcome to our incoming batch of Ph.D. students! (L-R) Manasadeepika, Shama, Chandrakanta, Blossom, Joyce, Lakshmi, Shweta Our e-book is out now! "MIND: The Gap" blends research, personal stories, and insights from our events to explore mental health holistically. Through the Looking Glass Art Exhibition Visit our art exhibition, running at the NIMHANS Heritage Museum from Oct-Nov 2024 in celebration of World Mental Health Day! Welcome to our incoming batch of Ph.D. students! (L-R) Deepankan, Shrinkhala, Pannaga (Not pictured) Rashmi, Blossom Coffee, Cinema and Community: Mental Health Redefined | July 15 - 21, 2024 From book talks to film discussions, and art exhibitions to storytelling workshops - let's talk about mental health, Bengaluru! New publication alert! Exploring the genetics of lithium response in bipolar disorders Dr Suhas G awarded 2024 Society of Biological Psychiatry Travel Fellowship Award Dr Bhagyalakshmi S awarded the 2024 WFSBP Young Investigator Award New publication alert! Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder Excited volunteers trying out the EEG caps at National Science Day celebrations Welcome to our incoming batch of Ph.D. students! (L-R) Akshayaa, Mythri, Lakshana, Shreevidya We were at the India Science Festival 2024 at IISER Pune! Srividya and Romita's farewell lunch - good luck & we'll miss you! Our Research Groups Clinical Group Endophenotype Group Genetics & Stem Cell Group Patients undergo extensive clinical investigations, including neuroimaging and neuropsychological assessments at regular intervals as part of a longitudinal study Learn More Advances in stem cell technology allow us to investigate specific molecular mechanisms underlying neuropsychiatric disorders and offer insights into genetic variations and their effects on neuronal functioning in neural cell models. Learn More Endophenotypic clues derived from various assessments enhance the reliability of research on brain function by offering insights into genetic factors of a psychiatric disorder Learn More Get involved in research! We're bringing together scientists, clinicians, members of the public, individuals with lived experiences and their caregivers to talk about our research in psychiatric and neurological illnesses. Sign up if you're interested in participating. Learn more about what PPIE is here Read more Do you want to participate in our research studies? Click here to learn more Opportunities Project Associate (Lab) Project Associate Contact

Welcome! Hello there 😊 You are now part of the MGL/ADBS/CBM group , and we are really glad to have you here! We hope your time here will be meaningful, fruitful, and filled with valuable learning experiences. We hope you will fully immerse yourself in this environment, which exists at the crossroads of psychiatry, psychology, genetics, epigenetics, stem cell research, and systems biology. Each of us, in different ways, is both a mentor and a mentee. We are equally responsible for shaping the collective dynamics of the group, one that is positive, engaging, challenging, rewarding, and free of hostility. The purpose of this document is to share our vision for mentor-mentee relationships within the MGL/ADBS/CBM group. What lies at the core of this vision? Three tenets: commitment to (I) professionalism and transparency, (II) mutual care, support, and respect, and (III) clear and polite communication of mutual expectations. Together, these will help us stay focused on what we came together to do: Science. Planning it well, doing it carefully, and sharing it openly. As the research group in charge, I (Biju) promise that I will try my best to: Support and care for your well-being as a person and as a scientist, and engage with you directly and kindly. Give you time for work discussions on a regular basis, and as needed. Support your career development through networking, recommendation letters, and conference participation. As both mentors and mentees, valued members of this community, I expect and encourage you to: Proactively seek time with me and others for work discussions. Respect your own time and that of others; communicate timelines clearly for work plans and be on time for meetings. Follow the due procedure for taking leave. Participate actively in lab life. Present your work, engage in discussions, join lab cleaning sessions, and social events, take part in outreach activities when you can, and help host visiting speakers. Address your colleagues (including PIs) by their first names, without salutations. This will help us foster a harmonious, non-hierarchical environment. Together, we can co-create a culture of small kindnesses – greet colleagues, offer help when you can, welcome newcomers, and celebrate each other’s wins, be it big or small. We are a large group balancing shared and individual priorities. So, naturally, conflicts will arise. When they do, or when you find yourself privy to a conflict involving others, I encourage you to resist the tendency to victimise, persecute, or rescue the parties involved. Instead, in a civil manner, invert this triad: create solutions, challenge, or coach them towards harmony. Encourage the parties involved to speak directly with each other. And yes, talk to me. Let me help you :) Mentees Expectations: Reflect on the kind(s) of mentorship that helps you grow. Every mentor-mentee relationship is different, and it’s okay to explore what works for you. If an approach is not helpful, share this openly, kindly, and clearly with your mentor. Talk to me when you want help with this. You may have one/more seniors working on the same/similar project as you, who are not your official guides. When they assign you any work, feel free to have a conversation about your work priorities and the time commitment expected from you. If you do not have the time required, know that you can voice the same clearly to them. Keep me in the loop through email. Seek help any time: “Help will always be given at MGL/ADBS/CBM, to those who ask for it”. Discuss with your mentors and me the kind of support you need for your success. Feedback is an ongoing part of learning, and we rely on your input. You’re encouraged to share what’s working and what could improve – both ways – so that we can grow together. Plans will evolve and change as science develops. This can be unsettling. When it does, talk to other mentors and me. We will go through it together :) Take ownership of your learning and research. Be curious, ask questions, and explore – that initiative can be the most stimulating part of your development as a scientist. Be open to being questioned about your work by juniors and seniors. It's thought-provoking. Helps you look at your work dispassionately and self-critically. It is a very important part of your learning. Ultimately, you may get the same comment from an external reviewer! Mentors Expectations: Proactively build your independent line of research and prioritise your time around that. Let me help you with it :) Share your knowledge, experience and expertise openly: none of us reached here without that little helping hand! Reflect on your experience as a mentee: what worked, what didn’t, and how that shaped your current mentoring approach. Remember how you felt then, not just what you know now. Let that decide your actions. Good mentors are built through training, reflection, patience, empathy, and creating a sense of community. There will be many types of mentorship styles. A suggestion, nevertheless: start meetings with your mentees by asking how they are doing and what their biggest challenges were that week. Ask for honest feedback from your mentees: about their lab experience and their perception of you as their mentor. It may not come naturally for your mentees to tell you directly what they think, especially if it is about you. Hear them out, sleep on it. When you need the help of a junior person: ask about availability before assigning any work. Clarify time commitments – how much of their time do you need, for how long (an estimate will do). Email their direct guide, copying me, and defining the work you need help with. Some additional points about general lab ethics for all You spend a lot of time in the lab, make it your home – take responsibilities, take ownership. Take care of lab properties – work desks, instruments, equipment, etc. Help out in service and repair activities. Keep the lab tidy – clear up after use, clean up after eating. Be honest. Reporting things as they are is at the core of doing science. No one will judge you for not knowing something. What matters is that you remain curious, transparent, open to new learning and changes, and develop the capacity to take responsibility. The same goes when you make mistakes at work or break something in the lab. Invest time in the success of the lab, as you do in your own research. So, look around, see what needs doing and what others are doing for you, and pitch in. It will always make a difference and will not go unnoticed. Complete your assigned lab work on time. The lab thrives when we pull our weights together. Please inform your mentee/mentor ahead of time when you cannot participate in group lab activities or some planned work. Do send leave mails. You could be juggling many things at the same time. You may have to negotiate clearly and openly with your mentor if there are additional responsibilities you are asked to take, in addition to your current workload. Try to respond to work emails/messages from me or your mentor/mentee within a reasonable time frame (24-48h) to ensure smooth communication. You are free to define your work hours, as long as there is steady progress towards your goals. Being present in the lab helps you learn from (and teach) other people – one of the best parts of doing science. Lock the lab when empty; safety is the utmost priority. Help in building a long-lasting and sustaining lab: ensure resources are used judiciously, and ensure your peers are mindful too. Ensure you are maintaining a well-recorded and legible lab record notebook. It is required to retain and pass on knowledge learnt in the lab - also to trace back when needed. Do not come into the lab when sick. Stay home and safe. Don’t risk getting others sick. Also, help out – take care of the wounded soldier next to you. There are always culturally embedded factors at play; remain open to new learning. Paper submissions Maintain an evolving PowerPoint file for your work. Send a new version to the team each time with additional slides rather than editing old ones; clearly label final figures, include legends, sample IDs, and write key takeaways to avoid confusion over time. Organise your references systematically so they are easy to retrieve when needed. Writing can be fun. It is a process. Allow yourself the time to figure that out; talk to your other mentors and me. Editing may take even longer than writing – get early, timely feedback on figures and results in group meetings and discussions with mentors. It would typically take multiple iterations of writing and editing with your co-authors. I / other mentors will help you. Lead authors (first author - solo or shared) need to develop a timeline early in the process, with your mentor(s) and corresponding author(s) on the paper. Plan backwards! Include time for all co-authors to review the manuscript once a draft is ready from your side. Pass it along to the co-authors and give them a minimum of 3 weeks to provide feedback. Confirm with your co-authors that their names and affiliations are spelt correctly. Plan as per your submission timelines and keep your co-authors informed of these timelines as well. Authorship needs to be discussed with your mentor(s)/corresponding author(s), co-authors. This includes agreement on whose names will be included and in what order. Both are important parameters for everyone’s career development. In some cases, it may be the corresponding authors who have this discussion with the authors, but the first author(s) need to be aware of the process. Remember, the final document has to be shared with all authors and approved by them before journal submission. Conference presentations Discuss the data and experimental plan needed for the poster with your mentor before the submission. Discuss the time commitments of your peers who are co-authors on the poster. Discuss points of authorship with your co-authors. This needs to be done in a timely manner, before an Abstract is sent out of the lab. When you send manuscripts (or abstracts) for review, add a relevant title that can be easily retrieved for future use (e.g., with version number/date, etc.). Remember to share the final copy of the submitted documents and details with all the authors involved. AI use statement I strongly request that all mentors and mentees resist the tendency to outsource reading, writing, and critical thinking skills to AI tools. To enjoy the process of doing science, utilising and challenging one's own cognitive & discretionary skills is crucial. AI is a tool which functions best in tasks where the process is clear from the start to the end. A known pathway of functioning. Like solving math problems and providing information about well-established facts. However, when the facts are obscure and with ambiguous data, AI will struggle in its current and foreseeable state. This is the kind of space where the use of our association cortex is unparalleled, giving us an edge which AI struggles to do. Several components of science remain controlled by variable factors. Examples: what led you to research a specific topic, how external scientists receive your scientific work, etc. But importantly, specific components of this process remain within our control. Examples: planning & executing experiments, analysing data & disseminating results through an original research article, and synthesising decades worth of literature in a review article. If one outsources these to AI tools, you lose the opportunity to develop foundational skills that stay with you, even when you're away from the screen. That being said, we are of the impression that AI does have several straightforward uses from which we could benefit. It can help you organise your time and write administrative emails. It can be used to check grammar and language skills to improve your literary prowess. It's good at writing code for simple, straightforward tasks. We do encourage learning more about how to use AI as a tool, as it is seemingly inevitable and would be a useful skill to possess. If you feel pressed to use AI tools because of a time crunch, difficulty in navigating reading material, work plans, etc., reach out to me & your team of mentors & mentees. Let's find ways to help you out. Acknowledgements This document takes inspiration and borrows text from Aly and Memo lab manuals.

Patient and Public Involvement & Engagement At the Centre for Brain and Mind, NIMHANS (CBM-NIMHANS), Public and Patient Involvement and Engagement (PPIE) shapes how we think about research, communication, and public dialogue on mental illnesses. Our work is informed by the understanding that knowledge in this field is produced not only through laboratories, clinics, and publications, but also through lived experience, community interaction, and everyday encounters with care and stigma. What is PPIE? Patient and public involvement and engagement is a research practice where people with lived experience (PwLE) of health conditions (patients), their caregivers, members of the public and communities work together with scientists at every stage of research. Rather than research being done about people, it is done with and for them. Within the Indian context of mental illness - where silence, hierarchy, and unequal access continue to influence who is heard - PPIE offers ways to engage more inclusively. Who can be involved? You don’t need any research background to get involved, and it’s not just for people with a mental health condition. Caregivers, family members, and others in the community all have valuable perspectives to share. Persons with lived experience (PwLE) of a mental illness Family members of PwLE Caregivers of PwLE People from communities & organisations that support PwLE Who does PPIE benefit & how? Involving patients and the public in research has multiple benefits for both researchers and those involved - Better quality of research More relevant research goals Brings real-world perspective to theoretical problems Increases accessibility to researchers and their work Provides accountability to the public If you’re a member of the public interested in PPIE If you are a patient, caregiver, or member of the public who is interested in joining the CBM-NIMHANS PPIE community, fill out our registration form here . If you’re a researcher interested in PPIE To learn more about our PPIE work or to explore potential collaborations, please email us at cbm.nimhans@gmail.com Resources UK Standards for Public Involvement Read More Involving People Read More Patient & Public Involvement Resources - PenARC Read More PPIE Resources for Researchers - NIHR Newcastle Read More Learning for Involvement - NIHR Read More To play, press and hold the enter key. To stop, release the enter key.

Contact Us Phone 080-26995791 Email cbm.nimhans@gmail.com Social Media First Name Last Name Email Message I want to subscribe to updates from CBM NIMHANS Send Thanks for submitting!

Clinical Group Endophenotype Group Genetics and Stem Cell Group Molecular disturbances involving multiple genes contribute to the complexity of psychiatric disorders, requiring a focus on cellular and molecular changes. Advances in stem cell technology allow us to investigate specific molecular mechanisms underlying neuropsychiatric disorders and offer insights into genetic variations and their effects on neuronal functioning in neural cell models using induced pluripotent stem cells (iPSCs). This offers potential for improved diagnostic and therapeutic approaches. How We Work Together Dr Biju Viswanath Lead Investigator, Bipolar Disorder Cohort Dr. Meera Purushottam Senior Scientific Officer, Molecular Genetics Lab, Department of Psychiatry Dr. Suhas Ganesh Clinician Scientist, MQ: Transforming Mental Health Fellow, Department of Psychiatry Dr. Reeteka Sud Lab Senior Scientist, Department of Psychiatry Facilities Hatai Microscope (Molecular Devices) Zeiss Microscope Centrifuge Novo Light Microscope Incubator Incubator Storage 4C Fridge Light Microscope Imaging System Centrifuge Hatai Microscope (Molecular Devices) Zeiss Microscope Centrifuge Novo Light Microscope Incubator Incubator Storage 4C Fridge Light Microscope Imaging System Centrifuge Hatai Microscope (Molecular Devices) Zeiss Microscope Centrifuge Novo Light Microscope Incubator Incubator Storage 4C Fridge Light Microscope Imaging System Centrifuge Hatai Microscope (Molecular Devices) Zeiss Microscope Centrifuge Novo Light Microscope Incubator Incubator Storage 4C Fridge Light Microscope Imaging System Centrifuge Affiliated Labs and Centre Molecular Genetics Laboratory (MGL) Bhalla Lab Padinjat Lab ADBS Data Centre Featured Publications Prasad G, P. et al. (2025b) “Unstable FGF14 GAA repeat expansions in Indian ataxia patients: a broader phenotype and involvement of modifier loci?,” Journal of Human Genetics, pp. 1–7. Available at: https://doi.org/10.1038/s10038-025-01390-6 . Parthaje, S. et al. (2025) “CAG Repeat Instability and Region-Specific Gene Expression Changes in the SCA12 Brain,” The Cerebellum, 24(3), p. 60. Available at: https://doi.org/10.1007/s12311-025-01808-z . Karunakaran, K.B., Jain, S., Widera, D. et al. Spatial and functional profiles distinguish target sets of Parkinson’s disease and antipsychotic drugs with different clinical effects. Transl Psychiatry 15, 124 (2025). https://doi.org/10.1038/s41398-025-03351-1 Cabrera-Mendoza, B. et al. (2025) “Equitable Collaboration Between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research,” American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, n/a(n/a), p. e33042. Available at: https://doi.org/10.1002/ajmg.b.33042 . Phalnikar, K. et al. (2024) “Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder,” Oxford Open Neuroscience, 3, p. kvae007. Available at: https://doi.org/10.1093/oons/kvae007 . Vinod, P. et al. (2024) “Does Apolipoprotein E polymorphism play a role in familial Alzheimer’s Dementia,” Alzheimer’s & Dementia, 20(S1), p. e087257. Available at: https://doi.org/10.1002/alz.087257 .

Genetics and Stem Cell Group Endophenotype Group Clinical Group Psychiatric disorders commonly emerge in young adulthood and significantly impact career choices and lifespan. Early onset of symptoms, usually before age 24, underscores the need for comprehensive support and intervention. The absence of a clear link between genes and observable traits makes treatment plans more complex. The neuropsychiatric disorders we study often have origins in early development, necessitating a shift towards understanding developmental trajectories. How We Work Together Dr Y C Janardhan Reddy Lead Investigator, Obsessive Compulsive Disorder Cohort Dr. Vivek Benegal Lead Investigator, Addiction Cohort Dr Biju Viswanath Lead Investigator, Bipolar Disorder Cohort Dr. PT Sivakumar Co-Investigator, Dementia Cohort Dr. Vijay Kumar K.G. Co-Investigator, Schizophrenia Cohort Dr Jayant Mahadevan Co-Investigator, Addiction Cohort Dr. Preethi V. Reddy Co-Investigator, Bipolar Disorder Cohort Dr. Lekhansh Shukla Co-Investigator, Addiction Cohort Dr. Srinivas Balachander Co-Investigator, Obsessive Compulsive Disorder Cohort Dr Suhas Satish Co-Investigator, Schizophrenia Cohort Dr. Vijaykumar S Harbishettar Co-Investigator, Dementia Cohort Affiliated Labs & Centres Department of Psychiatry, NIMHANS Schizophrenia & Metabolic Clinic Obsessive-Compulsive Disorder Clinic Centre for Addiction Medicine (CAM) Geriatric Clinic Featured Publications Nayok, S.B. et al. (2025) “Gaze fixation stability is a transdiagnostic marker of major psychiatric disorders: A high-density family-based study.” medRxiv, p. 2025.06.23.25330103. Available at: https://doi.org/10.1101/2025.06.23.25330103 . Durbagula, S. et al. (2024) “Genetic insights into male autism spectrum disorder in a small cohort of Indian simplex families: findings from whole exome sequencing,” General Psychiatry, 37(6), p. e101606. Available at: https://doi.org/10.1136/gpsych-2024-101606 . Muthukumaran, M. et al. (2024) “Shared deficits of education, marital and occupational functioning in unaffected siblings of multiple affected families with major psychiatric illness,” Asian Journal of Psychiatry, 101, p. 104216. Available at: https://doi.org/10.1016/j.ajp.2024.104216 . Lakkireddy SP, Balachander S, Dayalamurthy P, et al. Neurocognition and its association with adverse childhood experiences and familial risk of mental illness. Prog Neuropsychopharmacol Biol Psychiatry. 2022;119:110620. doi:10.1016/j.pnpbp.2022.110620 Vinod, P. et al. (2024) “Does Apolipoprotein E polymorphism play a role in familial Alzheimer’s Dementia,” Alzheimer’s & Dementia, 20(S1), p. e087257. Available at: https://doi.org/10.1002/alz.087257 .

About Us Through deep interrogation of brain networks via brain imaging and clinical electrophysiology as well as sub-cellular networks using molecular and cellular analysis, we aim to move towards a better mechanistic understanding of these disorders. These findings should lead to better diagnostic and therapeutic approaches for patients with psychiatric disorders as well as fundamental new insights into the function of the human brain. Changes in the structure and function of the brain that result in mental illness are poorly understood. Neither do we know why some individuals are more prone to developing mental illness than others. Studying these underlying changes in the brain will likely lead to better methods to diagnose and treat mental illness. Our Objecti ves Investigate Psychiatric Disorders & Establish Databases Establish and investigate a large cohort of families with severe psychiatric illnesses & healthy controls Establish an informative, digital database of research outcomes alongside a repository of biological samples Research Focus Understand the causes, connections and courses of severe psychiatric illnesses Explore potential interventions and treatments Advanced Techniques Employ advanced techniques in imaging, genetics, and stem cell biology towards understanding the cellular and molecular mechanisms behind these disorders Open Source and Collaboration Commit to openness and collaboration by making the database and repository open-source Emphasise public engagement and community outreach Nodal Centres Department of Psychiatry, National Institute of Mental Health and Neurosciences The National Institute of Mental Health and Neurosciences (NIMHANS) is a world-renowned, multi-disciplinary centre for patient care, academics and cutting-edge research in the field of mental health and neuroscience. With its history dating back to 1847, the Central Government recognized its eminent academic position, growth and contributions, and declared it a ‘Deemed University’ in 1994. In 2012, NIMHANS was conferred the status of an ‘Institute of National Importance’. National Centre for Biological Sciences The National Centre for Biological Sciences (NCBS), located in Bangalore, is part of the Tata Institute of Fundamental Research. Established in 1992, It is a premier research institute with research interests of faculty members lying in the frontier areas of biology, and the science at NCBS (a part of the Tata Institute of Fundamental Research) uses experimental and computational approaches in the study of molecules, cells and organisms. Funding Rohini Nilekani Philanthropies , led by Rohini Nilekani, is a catalyst for positive social change in India. With a focus on education, water conservation, healthcare, and social justice, the foundation collaborates with diverse stakeholders to implement innovative solutions. Prioritising community empowerment and amplifying marginalised voices, it strategically invests for lasting impact. Board of Advisors Prof Mriganka Sur Massachusetts Institute of Technology, Massachusetts, USA Prof Matcheri Keshavan Harvard Medical School, Massachusetts, USA Prof Mani Ramaswami Trinity College, Dublin, Ireland Prof PSVN Sharma Kasturba Medical College, Manipal, India

Facilities Clinical and Endophenotype Stem Cell Laboratory Molecular Genetics Laboratory Bioinformatics Stem Cell Laboratory Cell culture facility (80 m²) 1 A dedicated, sterile, air-flow controlled workspace for culture of primary and stem cells Biosafety Cabinets 4 Provide a sterile, air-flow controlled work environment for cell culture CO₂ Incubators 6 Provide a controlled environment to grow cells Fluorescence Microscopes 2 Used to visualise fluorescently labelled cells Phase-contrast Microscopes 2 Used to image live, unstained cells Neon Electroporator 1 Allows gene delivery via electroporation Amaxa Nucleofector 1 High-efficiency nucleic acid transfection Heated Incubators 3 Temperature-controlled storage/growth LN₂ Cryotanks 5 Long-term cryogenic cell storage Ultra-low Freezers (−80°C) 6 Biobanking at ultra-low temperatures −30°C Freezers 4 Medium-term sample storage Refrigerators 2 Sample and reagent storage High-content Imaging System 1 Automated, high-throughput cell imaging Autoclave 1 Equipment & media sterilization Spectrophotometer 1 Sample absorbance/concentration measurement Clinical and Endophenotype Facilities Eye Tracking Functional Near-Infrared Spectroscopy (fNIRS) Magnetic resonance imaging Philips Ingenia 3.0T CX MRI Electroencephalography

Digital Resources Select & de-select type of resource Article Book Brochure Event Pages Games & Activities Infographic Video Webinar Select & de-select target audience General Public Patients and Families/Caregivers Researchers Students Information about Psychiatric Disorders Infographic Brain Bridge Talks | Imaging Cognition to Investigate Psychosis by Professor Sagnik Bhattacharyya Webinar Brain Bridge Talks | Monoamines, Mitochondria and Mood by Dr Vidita Vaidya Webinar Brain Bridge Talks | Neuroimaging for Non-Invasive Therapeutics in Severe Mental Illnesses by Prof Lena Palaniyappan Webinar Brain Bridge Talks | The Neuroscientist's Guide to Schizophrenia by Dr. Jens Hjerling-Leffler Webinar Brain Bridge Talks | Unraveling the complexity using genetically diverse human cellular models Webinar Brain Bridge Talks | Unveiling Minds - Genetic Insights and Cellular Mechanisms Webinar Centre for Brain & Mind Brochure Brochure E-Book | Mind the Gap Book FAQ - Common Stigmas in Bipolar Disorder Video FAQ - Common Stigmas in Bipolar Disorder (Tamil) Video FAQ - Dealing with Suicidal Thoughts Video FAQ - Dealing with Suicidal Thoughts (Hindi) Video FAQ - Dementia Awareness & Public Health Initiatives Video FAQ - How to Seek Help For Addiction Video FAQ - Is Addiction A Disease? Video FAQ - Living a Healthy Life with Bipolar Disorder Video FAQ - Living a Healthy Life with Bipolar Disorder (Tamil) Video FAQ - Loneliness & Dementia Video FAQ - Suicide Awareness Video FAQ - Suicide Awareness (Hindi) Video FAQ - Supporting Dementia Caregivers Video FAQ - Supporting Dementia Patients Video FAQ - Tackling Stigma in Bipolar Disorder Video FAQ - Tackling Stigma in Bipolar Disorder (Tamil) Video Load More Useful Links Accelerator Program for Discovery in Brain Disorders (ADBS) Wellcome Collection Human Brain Project Big Brain RIKEN Center for Brain Science (CBS) Simons Center for the Social Brain BRAIN Initiative UK Biobank Psychiatric Genomics Consortium International Consortium on Lithium Genetics (ConLiGen) Allen Brain Map cVEDA Project A-BIG-NET IC-MAGIC

Learn more about upcoming events at the Centre for Brain and Mind - NIMHANS Upcoming Events इस समय कोई इवेंट नहीं है Past Events Brain Bridge: Talks by CBM NIMHANS | Prof Deepak Srivastava गुरु, 12 फ़र॰ Zoom Webinar विवरण Sci560: Science in the City शनि, 16 नव॰ Science Gallery Bengaluru This weekend scholars from NIMHANS will be at the Science Gallery Bengaluru for a series of programmes focused on mental health. Recordings of the events will be available on the Science Gallery Bengaluru website. विवरण Talk by Prof John Nurnberger | Genetics of Alcohol Use Disorder: Will Polygenic Scores Be Useful? गुरु, 14 नव॰ Platinum Jubilee Hall, NIMHANS Join us this Thursday at 5 pm at the Platinum Jubilee Hall, NIMHANS, Bangalore for an interesting talk on the genetics of alcohol use disorder by Prof John Nurnberger, Joyce & Iver Small Professor Emeritus of Psychiatry, Indiana University School of Medicine विवरण Talk by Prof Vidita Vaidya | Monoamines, Mitochondria and Mood शुक्र, 06 सित॰ Platinum Jubilee Hall, NIMHANS Join us for a riveting talk on "Monoamines, Mitochondria and Mood" by Professor Vidita Vaidya, from the Tata Institute of Fundamental Research, Mumbai. विवरण Stories in Motion: Mental Wellness through Art and Narratives by Dr. Ankit Dwivedi रवि, 21 जुल॰ Bangalore International Centre REGISTRATIONS OPEN ONLINE | Experience the power of storytelling in understanding mental health with Dr. Ankit Dwivedi, a professional storyteller and researcher. This interactive workshop will explore the nuances of mental health through engaging storytelling. विवरण अधिक लोड करें