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  • Centre for Brain and Mind - National Institute of Mental Health and Neurosciences (CBM NIMHANS)

    Welcome Updates Research Events Jobs Rohini Nilekani Centre for Brain and Mind About Us The Centre for Brain and Mind is a collaborative, premier research centre focused on supporting research on five mental disorders — schizophrenia, bipolar disorder, addiction, obsessive-compulsive disorder and dementia. With a partnership between the National Institute of Mental Health and Neurosciences (NIMHANS) and the National Centre for Biological Sciences (NCBS), the centre employs several tools & techniques to understand the complexities of brain and mind conditions. Learn More Introduction New at CBM Through the Looking Glass Art Exhibition Visit our art exhibition, running at the NIMHANS Heritage Museum from Oct-Nov 2024 in celebration of World Mental Health Day! Welcome to our incoming Ph.D. batch of 2024! (L-R) Deepankan, Shrinkhala, Pannaga (Not pictured) Rashmi Coffee, Cinema and Community: Mental Health Redefined | July 15 - 21, 2024 From book talks to film discussions, and art exhibitions to storytelling workshops - let's talk about mental health, Bengaluru! New publication alert! Exploring the genetics of lithium response in bipolar disorders Dr Suhas G awarded 2024 Society of Biological Psychiatry Travel Fellowship Award Dr Bhagyalakshmi S awarded the 2024 WFSBP Young Investigator Award Dr Biju Viswanath talked about discovering the biology of neuropsychiatric illness in India as part of the presidential lecture series at SCRA 2024 New publication alert! Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder Excited volunteers trying out the EEG caps at National Science Day celebrations Welcome to our incoming Ph.D. batch of 2023! (L-R) Akshayaa, Mythri, Lakshana, Shreevidya We were at the India Science Festival 2024 at IISER Pune! Srividya and Romita's farewell lunch - good luck & we'll miss you! Our Research Groups Clinical Group Endophenotype Group Genetics & Stem Cell Group Patients undergo extensive clinical investigations, including neuroimaging and neuropsychological assessments at regular intervals as part of a longitudinal study Learn More Advances in stem cell technology allow us to investigate specific molecular mechanisms underlying neuropsychiatric disorders and offer insights into genetic variations and their effects on neuronal functioning in neural cell models. Learn More Endophenotypic clues derived from various assessments enhance the reliability of research on brain function by offering insights into genetic factors of a psychiatric disorder Learn More REGISTER HERE Do you want to participate in our research? Click here to learn more Opportunities No open positions at the moment. Contact

  • About Us | CBM NIMHANS

    About Us Through deep interrogation of brain networks via brain imaging and clinical electrophysiology as well as sub-cellular networks using molecular and cellular analysis, we aim to move towards a better mechanistic understanding of these disorders. These findings should lead to better diagnostic and therapeutic approaches for patients with psychiatric disorders as well as fundamental new insights into the function of the human brain. Changes in the structure and function of the brain that result in mental illness are poorly understood. Neither do we know why some individuals are more prone to developing mental illness than others. Studying these underlying changes in the brain will likely lead to better methods to diagnose and treat mental illness. Our Objecti ves Investigate Psychiatric Disorders & Establish Databases Establish and investigate a large cohort of families with severe psychiatric illnesses & healthy controls ​ Establish an informative, digital database of research outcomes alongside a repository of biological samples Research Focus Understand the causes, connections and courses of severe psychiatric illnesses Explore potential interventions and treatments Advanced Techniques Employ advanced techniques in imaging, genetics, and stem cell biology towards understanding the cellular and molecular mechanisms behind these disorders Open Source and Collaboration Commit to openness and collaboration by making the database and repository open-source Emphasise public engagement and community outreach Nodal Centres Department of Psychiatry, National Institute of Mental Health and Neurosciences The National Institute of Mental Health and Neurosciences (NIMHANS) is a world-renowned, multi-disciplinary centre for patient care, academics and cutting-edge research in the field of mental health and neuroscience. With its history dating back to 1847, the Central Government recognized its eminent academic position, growth and contributions, and declared it a ‘Deemed University’ in 1994. In 2012, NIMHANS was conferred the status of an ‘Institute of National Importance’. National Centre for Biological Sciences The National Centre for Biological Sciences (NCBS), located in Bangalore, is part of the Tata Institute of Fundamental Research. Established in 1992, It is a premier research institute with research interests of faculty members lying in the frontier areas of biology, and the science at NCBS (a part of the Tata Institute of Fundamental Research) uses experimental and computational approaches in the study of molecules, cells and organisms. Funding Rohini Nilekani Philanthropies , led by Rohini Nilekani, is a catalyst for positive social change in India. With a focus on education, water conservation, healthcare, and social justice, the foundation collaborates with diverse stakeholders to implement innovative solutions. Prioritising community empowerment and amplifying marginalised voices, it strategically invests for lasting impact. Board of Advisors Prof Mriganka Sur Massachusetts Institute of Technology, Massachusetts, USA Prof Matcheri Keshavan Harvard Medical School, Massachusetts, USA Prof Mani Ramaswami Trinity College, Dublin, Ireland Prof PSVN Sharma Kasturba Medical College, Manipal, India

  • Genetics and Stem Cell Group | CBM NIMHANS

    Genetics and Stem Cell Group Molecular disturbances involving multiple genes contribute to the complexity of psychiatric disorders, requiring a focus on cellular and molecular changes. Advances in stem cell technology allow us to investigate specific molecular mechanisms underlying neuropsychiatric disorders and offer insights into genetic variations and their effects on neuronal functioning in neural cell models using induced pluripotent stem cells (iPSCs). This offers potential for improved diagnostic and therapeutic approaches. Dr Biju Viswanath Lead Investigator, Bipolar Disorder Cohort Dr. Meera Purushottam Senior Scientific Officer, Molecular Genetics Lab, Department of Psychiatry Dr. Suhas Ganesh Clinician Scientist, MQ: Transforming Mental Health Fellow, Department of Psychiatry Dr. Reeteka Sud Lab Senior Scientist, Department of Psychiatry Affiliated Labs and Centre Molecular Genetics Laboratory (MGL) Bhalla Lab Padinjat Lab ADBS Data Centre Facilities Sanger Sequencing SeqStudio Flex 24-cap Genetic Analyzer High-capacity computational cluster Master Node: CPU: 4x Intel Xeon Gold 6150, 144 cores Memory: 2TB DDR4 ECC @ 2666 MT/s Storage: 20TB SSD + auxiliary SAN Storage:500TB via LVM Compute Nodes (2): CPU: Dual Intel Xeon Gold 5115, 40 cores each Memory: 128GB DDR4 ECC @ 2666 MT/s each Storage: 1TB SSD each Integrated with SAN Storage for data management Cell Culture Facility Biosafety Level 2 Inverted Fluorescence Microscope Sample Biorepository Liquid Handling Robot epMotion 5075 Genetic Analyzer 3500xl Genetic Analyzer for Human Identification Featured Publications Janardhanan M, Sen S, Shankarappa B, Purushottam M. Molecular genetics of neuropsychiatric illness: some musings. Front Genet. 2023;14:1203017. Published 2023 Nov 1. doi:10.3389/fgene.2023.1203017 ​ Shankarappa B, Mahadevan J, Murthy P, et al. Hypomethylation of Long Interspersed Nucleotide Elements and Aldehyde Dehydrogenase in Patients of Alcohol Use Disorder with Cirrhosis. DNA Cell Biol. 2023;42(7):364-371. doi:10.1089/dna.2022.0669 ​ Sukumaran SK, Paul P, Guttal V, et al. Abnormalities in the migration of neural precursor cells in familial bipolar disorder. Dis Model Mech. 2022;15(10):dmm049526. doi:10.1242/dmm.049526 ​ Ratna N, Pasupulati SL, Nadella RK, Purushottam M, Jain S. Complexities in Genetic Counseling and Testing of Huntington's Disease: A Perspective from India. Neurol India. 2022;70(5):2141-2144. doi:10.4103/0028-3886.359184 ​ Paul P, Iyer S, Nadella RK, et al. Lithium response in bipolar disorder correlates with improved cell viability of patient derived cell lines . Sci Rep. 2020;10(1):7428. Published 2020 May 4. doi:10.1038/s41598-020-64202-1 ​ Timothy A, Benegal V, Shankarappa B, Saxena S, Jain S, Purushottam M. Influence of early adversity on cortisol reactivity, SLC6A4 methylation and externalizing behavior in children of alcoholics. Prog Neuropsychopharmacol Biol Psychiatry. 2019;94:109649. doi:10.1016/j.pnpbp.2019.109649 ​ Viswanath B, Rao NP, Narayanaswamy JC, et al. Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science. BMC Psychiatry. 2018;18(1):106. Published 2018 Apr 18. doi:10.1186/s12888-018-1674-2 ​

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